#21. Kavinace

by NeuroScience
8.49 out of 10 based on 74 user ratings
Written by: Brain Research Supplements
Date Published: 2011-06-17
Kavinace is an amino acid approach to brain nutrition supplementation designed to assist with sleep problems, anxiousness and stress. The description of this supplement states that it is able to deliver on the advertised benefits by supporting optimum GABA levels, the chief inhibitory neurotransmitter. The formula offered by NeuroScience contains a derivative of this naturally occurring neurotransmitter, known as Phenibut, which can easily cross the blood brain barrier to produce the wanted effects.
8.49 / 10 stars
Kavinace Review

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Kavinace is an amino acid approach to brain nutrition supplementation designed to assist with sleep problems, anxiousness and stress. The description of this supplement states that it is able to deliver on the advertised benefits by supporting optimum GABA levels, the chief inhibitory neurotransmitter. The formula offered by NeuroScience contains a derivative of this naturally occurring neurotransmitter, known as Phenibut, which can easily cross the blood brain barrier to produce the wanted effects.

Is Kavinace Right For You?

Kavinace is advertised as an powerful amino acid approach to brain nutrition supplementation. This brain supplement is claimed to be effective in promoting restful sleep and in reducing stress and anxiousness by supporting proper GABA levels. The company behind this product is NeuroScience.

According to their official website, this manufacturer is specialized in neurotransmitter clinical research and in the development of medical programs for some of today’s most challenging health conditions. The company’s product portfolio features several claimed “best sellers” such as TravaCor, AdreCor, Calm-PRT, Kavinace, Serene, LoraQuil, and GabaMax.

We were unable to find a dedicated website for the manufacturer, which, in an era where online presence is essential for any business, can be regarded as a shortcoming. Nonetheless, the reputation of this manufacturer and its good practices are a direct consequence of the positive image its numerous premium formulations hold among consumers.

NeuroScience claims this product is one of their “best calming supplements.” But the official statement goes beyond that and advertises Kavinace as a “uniquely designed to enhance GABAA and GABAB receptor function,” as well as promote healthy GABA levels.

According to the company, this formulation is different from traditional GABA supplementation, however no arguments are offered to support this claim.


Ingredients of Kavinace

Kavinace includes the following ingredients: Proprietary blend (Taurine and 4-amino-3-phenylbutyric acid), microcrystalline cellulose, vegetable cellulose, and magnesium stearate.

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Kavinace 4.25/5 (85.00%) 4 votes
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74 User Reviews or Add One about #21. Kavinace

  1. 1

    Ruth Mills


    I am 59 yrs old and a life-long insomniac. I am not a stressful person, quite the opposite content, happy, and optimistic. Just could not go to sleep,nor stay asleep. Prescription sleep pills work opposite and I have tried every natural homeopathic remedy without success. A month ago, my Dr gave me Kavinace Ultra PM – and I have slept soundly almost every night. Amazing stuff. Sleep definitely makes a difference in your overall health.

  2. 2

    Does anyone else get weird and vivid dreams? It has helped me sleep but after reading a lot of these comments, I think I will discontinue using it.

    • 5

      Bruce Ogletree


      My sleep specialist recommended I use Kavinace along with Trazadone (1-2 tablets of each at bedtime) to alleviate my insomnia and it works very well. I have not noticed any side effects.

  3. 7

    I have taken Kavinace and Kavinace Ultra PM for years now and have had a phenomenal experience with both. I don’t feel any side affects. They have helped me sleep and reduced my anxiety dramatically (along with other supplements). Obviously Kavinace affects people differently, so it is on a case-by-case basis. I haven’t had any dependency on Kavinace either. Sometimes I will run out of supplements, not take them for a few weeks, and I never have any problems.

  4. 8

    Carol Bowring


    I have stress cardiomyopia (broken heart syndrome and panic attacks. If I take the daytime Kabinace it lessens the intensity of the panic attacks, But I am grogged and sleepy all day. I took one nightime one and dell and hit my head trying to go to the tile bathroom 1t 3:00 a.m. I don’t take the nightime one since that incident. But my natural health specialist wants me to continue the daytime 4 x day. But I am week and sleepy all day. What is in the daytime one that makes me so limp and wasted all day? The only good thing is that it makes the Panic
    Attacks less intense. Any suggestions?

  5. 9



    I was prescribed Kavinace by a Naturopathic physician. It was prescribed primarily as a sleeping aid, secondly to assist in my valium taper. It worked beautifully for both situations. The first time I took it, it helped immediately. More recently, I found I needed some time for it to build up in my system before it became effective – but it did. Great product.

  6. 11

    I take Kavinace after doing the pendulum test to see if I need it that time. put your left hand over the solar plexus add the right, then while standing breathe deep 2-3 times, if you sway forward its good for you at that time, if you sway backwards, not for you at that time. donna eden energy medicine technique

  7. 12

    I’ve been using Kavinace to fall asleep for at least 5 years now. (hubby snores) I can fall asleep and stay asleep most of the time unless something is really really bothering me. So now I only take one. Love this stuff. I can fall asleep in less than 10 minutes, sleep through the night and feel fine in the morning. I just take the regular one, not the PM. My son just started taking it during the day if he’s stressed and it helps a lot with mood and anxiety. It wouldn’t let me, so I am telling you it should be rated with 5 STARS!!

  8. 13

    I have always had sleep issues, Nothing over the counter worked so i took Ambien. My niece talk me about Kavinace. It works great for me!!!

  9. 14

    I have only been taking this product for abt a week or two . I’m taking it at bedtime as well as also taking Calm G twice a day. I have gained about 4 pounds in a week. Does this cause weight gain? I am sleeping better and feel better during the day. But…. Have worked to lose some weight in the recent past and do not want to gain it back.

  10. 15

    Angie Guy


    I tried the Kavinace PM several times. It didn’t work well for me. It made me relaxed but didn’t make me tired enough to fall asleep. The next day I was an absolute wreck! Groggy, dizzy and nauseated. I don’t really know which ingredient made me feel so lousy but I did give these supplements an honest try. I took them at least four times with the same side effects. Sorry it didn’t work cause I’m still sleepless in Clearwater.

    • 16

      I had the exact reaction. Slept fitfully and then experienced extreme drowsiness, stomach upset and felt DRUGGED!! I will resort back to a 1/4 Zanax.

      • 17

        I had the same reaction along with horrible muscle tension. My holistic dr recommended it and it’s horrible. I had to leave work the second day I took it because I couldn’t think. It’s not worth the money or dangerous side effects.

  11. 19

    I have been taking Kavinace PM for a little over a year. It was recommended by a high priced “naturopath” who reassured me she has never seen anyone have any problems with it. I began with one, but then needed two, then needed three. When I realized I was going to need a 4th to sleep through the night, I stopped taking it. HORRIBLE. For the last two weeks I can’t sleep, and I’m feeling severe muscle tension and depression. Come to think of it, the whole time I took it I was having some serious gastrointestinal symptoms including acidity and diarrhea. Finally I returned to taking just one, but am still having pretty serious symptoms. I do not recommend this drug. We just don’t know that much about it.

  12. 20

    I initially got this from a naturopath MD for chronic insomnia. I had taken ambien for over 10 years on a nightly basis and that was all that helped me sleep. Now the family practitioner refuses to prescribe ambien anymore because of new FDA warnings. So I started taking two Kavinace at bed time and I am sleeping better than with Ambien. My big question is ordering this at various online vendors. Is it the same quality as what the doctors get from NeuroScience’s order site at Neurorelief.com? I no longer can see the naturopath and have no other way to get the Kavinace and they are truly the best sleep aid in the world for me.

  13. 21

    My NP had me try Kavinace to help get more deeper sleep and help with stress and anxiety. I was taking two pills at dinner time and noticed if I took it later in the evening or without food, I was so sleepy the next day. She lowered me to one pill and I take with food at 5 pm and I notice a huge difference when I sleep. So far….so good.

  14. 22

    I was on cymbalta to help with nerve pain, and when I got off of it, I couldn’t sleep well after that. I tried everything and finally someone told me about Kavinace PM. It works like a charm. I sort of have a hard time getting up in the morning, but it’s not too bad. I would rather feel well rested and a little groggy than not rested at all, which was miserable. I’m trying to figure out what to do from here because I would like to get pregnant again and want to stop taking it. I typically take one pill a night, but every now and again I don’t need it. Any suggestions for getting off of it and being able to sleep? Ha!

  15. 24

    Meghan Chandler


    I sleep like a log for about 9-10 hours and I wake up sluggish so two weeks ago I put my alarm clock for 7 am and I exercised feeling energized after that and then I took 1 cup of coffee . Because I am anxious a doctor recommended me to take Kavinace and after seeing your comments I believe if I take it I would sleep all day and all night, so I am not going to take it because I don’t need to sleep more.
    So, I am going to continue controlling my sleep, 7 hours is just fine for me and I am energized and less anxious during the day. Sleeping like I was doing for 9-10 hours is debilitating to the brain and the body.
    thanks for listening.

  16. 25

    Thank you so much for your posting on the addictive properties of Kavinace. Starting about six months ago, I took Kavince (one pill) for sleep disturbance and more recently took Kavinace ultra pm for same as it has melatonin and 5 htp in it, which I was taking anyway. All in one, great huh? Well, not so great as only recently have begun to experience queasy feelings in the afternoon, even after a good night’s sleep. Very difficult to describe but just not like myself. I am normally a high energy person and I felt lethargic, strange, etc. I stopped taking Kavinace three days ago and am experiencing what I can only describe as “withdrawal.” Back to the melatonin and 5 htp, old amino acid friends, sleeping even better now.

  17. 26

    Tom Schwald


    I had been on Alprazolam for over 41/2 years,but was able to stop taking it altogether.Thanks to replacing it with Kavinace.Just one in the morning & one before bed

    • 27


      Would you please share your experience stopping Alprazolam with the help of Kavinance?
      I really appreciate it!!!

      Thank you!

  18. 28

    Albert Hardy


    NeuroScience company does have a web site – neurorelief.com
    I don’t work for them nor do I wish to promote them; just providing information missing from your article. No need to post my review. But I am happy with how Kavinace works for me.

  19. 29



    I started taking Kavinace a few months ago, on and off every week to help get through the night after a pelvic fracture. It helped me sleep very deeply, both at night and during long daytime naps. I’ve actually never been able to nap so well. But recently (I’ve taken it twice in two weeks) if I take one Kavinace and don’t fall asleep right away, I start to feel like I can’t breathe. My body is trying to relax into a deeper state and sometimes I even feel a strange “thump” like an arrhythmia, and then my breathing is just heavy and slow. Eventually I fall asleep and have a wonderful, deep night’s rest, but the period before falling asleep is alarming and I don’t think I’ll take it again since it seems to be disturbing my heart and breathing rhythms. Anyone else have this?

    • 30

      From what I’ve read about the main ingredient, “Phenibut” it is the cause of those symptoms you are having. I started having similar effects — like I couldn’t catch my breath (even as I was trying to fall asleep), and also the irregular heartbeats. That’s when I researched this product that I had been told is safe and learned that people can develop a dependency on it and that the withdrawal effects can be terrible (and maybe even dangerous, if you try to stop cold-turkey).

  20. 31

    Barbara Adams


    Kavinace made me sleep like a baby, BUT I felt drunk and unable to focus during the day. I took it for three nights and the fourth night I took it and could not sleep at all. I had the usual racing thoughts. I stopped taking Kavinace and it took me a week to feel normal and focused again.

  21. 32

    I’ve struggled with sleep issues my entire life. Recently diagnosed with RLS, PLMD’s and sleep apnea. Was on medication to calm the RLS and PLMD’s which was then exaggerated by the CPAP. On the suggestion of a local homeopathic pharmacy I tried the Kavinace PM supplement and not only did it help me sleep, it reduced my glucose levels which were all out of whack because of my sleep issues, it also helped the RLS. I am no longer taking the prescription meds for the RLS. I am grateful for stumbling onto the Kavinace PM. It may not work for everyone, but again everyone’s sleep issues are not the same.

  22. 33

    This works. I have anxiety and panic disorder, and all the typical symptoms (irritability etc) and just one pill can significantly reduce my symptoms. Phenibut is real, is a prescription drug in russia, and works well. However, one can be dependent on it, and you shouldn’t take it for extended periods of time.

  23. 34

    I use Kavinace as prescribed by my doctor. I am dealing with peri-menopause and battling with related symptoms including shaking and insomnia. I get wonderful results. It reduces my shaking, calms my brain and helps me sleep. I highly recommend it and love that it’s not a drug.

    • 35

      Kavinace IS a drug! Google “Phenibut” (the main ingredient) and “withdrawal” or “addiction.” I have been taking it five months at my naturopath’s recommendation and developed a tolerance to it and had to increase my dose. Now I am facing withdrawal symptoms to quit taking it. From what I’m reading, it’s not safe to stop cold turkey. It is similar to Benzos from what I’m reading. It is only for occasional use, but most of us were/are taking it every night. I’m very concerned that info about the addictive nature of this supplement is not offered more freely by its manufacturer. If I’m reading the info about its addictiveness incorrectly, feel free to let me know.

  24. 36



    I have been taking it as recommended but I feel out of it. I have just started taking it….does that have something to do with it? Maybe I should only take one pill a day and not two? Any advice?

  25. 37

    some random bob


    Got sick once and couldn’t sleep very well ever since. I kept waking every hour or so every night so my doctor had me try kavinace ultra pm and it works so well.

  26. 38

    Excellent!, I believe all things do not have the same effect for all people. I was never a user of drugs except tylenol or aspirin for an occasional headache. I began taking phentermine for weight loss, Kavinace tkes me down from the phentermine “speed” high and I sleep like a baby. I found out the way to clear phentermine from the body is to use caffeine or amino acids. This works.

  27. 39

    I have suffered from insomnia related to Fibromyalgia for years. My physician had me try Kavinace Ultra Pm. It is amazing. I have tried everything out there .
    I have been taking it for over a year now and it is a Godsend.
    I feel calm and well rested when I wake up.completely natural and no side effects. Should invest money in this company.

  28. 41

    I have been using it for about a year. I sometimes take it to get a good, restful night sleep, and it always works. It is also great for panic disorder and anxiety. I have my children take it when they feel anxious or just have trouble sleeping. It’s a great product, we don’t take it everyday, but maybe once or twice a week. I highly recommend it.

  29. 42

    I’ve been struggling with insomnia that has gotten progressively worse over the years. I tried so many natural supplements that didn’t work that I finally went on Trazadone which really helped me sleep, but gave me horrible dreams and then headaches after taking it for a few months. I’ve been using this for a couple of weeks and so far, aside from one night, I’m sleeping great. I hope this keeps up. I would definitely recommend trying it.

  30. 43

    I have been taking Kavinace Ultra PM for over a year. The first time I took it was on vacation and slept for over 10 hours without waking up and that was in a hotel. I have not had a good nights rest in a very long time. It works really well for me. I wake up feeling really refreshed and well rested. I hate the price but make some sacrifices to purchase it.

  31. 44

    Hey I’ve been taking this stuff for like two years I have horrible insomnia and I’m 15 is that safe. I take two a night and can’t sleep with out it. My doctor recommended it to me but I don’t know lately I’ve just been worried about its long term effects.

  32. 46

    I’m 15 years old, and I have major depression and anxiety disorder. Whenever I get into a panic attack I take a kavinace and although it may take a minute, it works wonders. It calms me down, gets me back to normal, and I usually have a better night’s sleep.

  33. 47

    Kavinace is one of the five supplements that my parents insisted I should take during the school year. Little do they know it was the only one I took. Partly because I though taking five different pills is insane, but also because I felt Kavinace was good enough for me. I had a perfect year with no incidents.

  34. 48

    The lack of sleeping is becoming an issue lately, because it really affects my performance at work and also my nerves. Kavinace has helped me with the sleeping problem and also the other unwanted effects has all go away. Thanks!

  35. 49

    This is a great formula for sleep. I sleep like a baby and I feel more energized during the day and ready to face whatever comes along. My levels of anxiety decreased and I feel calmer and happier.

  36. 50



    As a sleep aid it is one of the most effective supplements near this price point. I have tried many other and I can say for sure that you can find none better. It also has other good effects like making yo more relaxed during the day.

  37. 51

    I used to have trouble sleeping every night. When I got into be I was unable to keep my eyes closed and I would twist and turn for a few hours before I could fall asleep. Kavinace has changed that a lot and now I fall asleep in less than half an hour.

  38. 52

    I have fought anxiety for more than a year before taking Kavinace. I have jumped from prescription drugs to natural remedies and back and forth a couple of times because of side effects and lack of effectiveness. Kavinace however did it for me. I am well enough to deal with anxiety myself and I don’t feel like a walking corpse either. Marvelous.

  39. 53

    I started getting anxious when I started to hold presentations during college. Back then I used to take very potent drugs to calm me down but that turned me into a zombie. Nowadays I take Kavinace when I need to relieve anxiety and I don’t have to worry about any side effects.

  40. 54

    I don’t take supplements, but my sister recommended this to me and it’s been quite a good month for me. I don’t know if I’ll continue because the price is pretty high, but It’s an ok product and you may consider giving it a try.

  41. 55

    Damn this is expensive. I’m lucky my parents got if for me. The product itself is very potent and has a very fast onset when compared to other similar products. I used it successfully every single time and I recommend it if you can take the cost.

  42. 56

    My colleagues basically force fed my Kavinace because I was always shouting at them randomly over the most trivial stuff. I didn’t think it will work but I did not want to argue with them any more. In the end, I calmed enough for them to be satisfied, although I wish It was a little more potent.

  43. 57

    Sleeping aids have been for me kind of a “love it or hate it” affair. Despite similar ingredients and concentrations, some have provided adequate relief, some had no effects. Kavinace not only does work exactly as it should, it also maintains its effects over a long period of time. So far it;s the best I’ve tried and I see no reason for trying something else.

    • 58

      I have been taking one in am and one in pm and feel very stable and level and the mega-stress I’ve been experiencing is certainly under control, BUT I have noticed a decline in my memory – like it’s sluggish and slow. I’m thinking perhaps the relaxing the pill does to me is also relaxing the memory part of my brain?? Has anyone else experienced this over time? I’m not on much other suppliments and no meds so I can honestly attribute the memory loss to this at least in my way of thinking.. Also, I have had stomach upset in the night come to think of it..

  44. 60

    Collin S.


    It’s quite good at relieving anxiety and it also helps me sleep. It’s an ok product, i recommend it.

  45. 61

    With Kavinace, I get a restful night’s sleep which allows me to better focus on my work during the day. I only take the pills in the evening because they make me drowsy.

  46. 62

    I ordered Kavinace because I was tired of the side effects of other drugs, stomach upsets, dry mouth… I don’t think it’s as potent as other pills I have tried, but I intend to keep taking it nonetheless.

  47. 63

    I use this after a super stressful day and when I know I’m going to have trouble sleeping. I take 1 tablet on an empty stomach 20 to 30 minutes before going to bed and I sleep great without any side effects. I don’t have chronic sleep problems or tons of anxiety so for me, this works as a good supplement when things get crazy.

  48. 66



    This helped me to get extra sleep once I started to take it each day. You need to wait a week for it to kick in but after that you should get the same results as me.

  49. 67

    I wish I had read the review above before I order this from the internet. I think I would have thought twice about getting it. I like the review you posted and it makes sense to me. I will read more of what you recommend and see what best fits my needs.

  50. 69

    I am a real nervous persona and always needed to have something to calm me. I am thru with the doctors drugs so I hope this helps.

  51. 71

    I go this supplement since it said it would promote sleep and reduce anxiousness. This is what I really want but I want left with these things. I think I wasted my money on this one.

  52. 73

    Yes, I have noticed the stomach acid after taking it too. It’s not all the time, but sometimes. I have been taking it for years and am worried that I am dependant on it. It looses its effectiveness after about 3 weeks. I take a break for a few nights; either I don’t sleep well or I take an Ambian for a couple of nights then go back to kavinace pm. I wish I could sleep unaided.

  53. 74



    Rae, I am in my seventies and had not been able to sleep all night since my early to mid fifties thanks to menopause. This went on for almost twenty years until I found out about Kavinace Ultra PM. I’ve been on it now for a little over two years and during that time I’ve had to get off of it for short periods in order to get it to work again. The first time I went off for a full month and of course I didn’t get much sleep and was miserable. Later, I found out I could get off of it for two weeks and it was like new all over again although the grogginess wasn’t as bad. I, too, have noticed some stomach acid but didn’t attribute it to the Kavinace until it was mentioned on this website. So now I’ll just have some yogurt before bedtime. I suffer from reflux from time to time and this has been my solution which works for me. Kavinace is a blessing for me but I’ve found that it doesn’t work for everyone and works differently for those for whom it does work. I would just like to know how long I can take it without any problems/side effects.

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